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pentobarbital will reduce the level or influence of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Pitolisant publicity is lessened by fifty% if coadministered with potent CYP3A4 inducers.buprenorphine subdermal implant and pentobarbital equally increase sedation. Prevent or Use Alternate Dru